黄夹次甙乙 用途与合成方法 |
生物活性 | Neriifolin 是一种穿透中枢神经系统的强心苷,是一种Na+, K+-ATPase 的抑制剂。Neriifolin 可靶向 beclin 1,抑制 LC3 相关吞噬体的形成,改善实验性自身免疫性脑脊髓炎 (EAE) 的发展。Neriifolin 诱导人肝癌 HepG2 细胞周期阻滞和凋亡。 |
体外研究 | Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins.
|
植物提取物百科 全球最大的植物提取物中文网 stephenture@qq.com
Copyright © 2020-2024 zwwiki.Cn All Rights Reserved