银杏素

更新时间: 2024-09-26 20:50:37 责编：网友投稿浏览

银杏素

银杏素用途与合成方法

生物活性

Ginkgetin 是一种从银杏叶中分离得到的双黄酮。Ginkgetin 具有抗肿瘤，抗炎，神经保护，抗真菌的作用。Ginkgetin 也是一种有效的 Wnt 信号抑制剂，IC50 值为 5.92 μM。

靶点

Wnt

5.92 μM (IC 50 )

体外研究

Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G 2 /M cell cycle arrest in Daoy cells.
Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner.
Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells.
Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner.
Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549.

Cell Viability Assay

化学性质	可溶于甲醇、乙醇、DMSO等有机溶剂，来源于银杏。
用途	银杏双黄酮具有调血脂，降胆固醇，治疗心绞痛的作用。
用途	用于含量测定/鉴定/药理实验等

中草药成分