棕矢车菊素

更新时间: 2024-09-26 20:56:09 责编：网友投稿浏览

棕矢车菊素

棕矢车菊素用途与合成方法

应用

从艾叶中分离得到的棕矢车菊素和异泽兰黄素属于环烯醚萜苷类，其主要具有清热、镇痛等相关活性作用。

棕矢车菊素

生物活性

Jaceosidin 是从 Artemisia vestita 中得到的黄酮类化合物，可激活 Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。Jaceosidin 具有抗癌和抗炎作用，能够降低炎性因子水平，激活 NF-κB，抑制 COX-2 的表达。

靶点

Bax

COX-2

体外研究

Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells.
Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation.
Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity.
Jaceosidin shows cytostatic activity to HES and HESC cells with IC 50 s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC 50 , 70.54, 147.14 μM, respectively), after treatment for 48 h.

Cell Viability Assay

体内研究

Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice.
Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice.
Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats.

用途	棕矢车菊素具有降血脂的作用。
用途	用于含量测定/鉴定/药理实验等。药理药效:抗肿瘤，抗氧化、清除氧自由基。

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